Effect
Vasoconstrictor, antiallergic, anti-
Composition
Diphenhydramine + Naphazoline
Dosage form
Drops for the eyes and nose 10 ml.
Pharmacological properties of
Pharmacokinetics
When applied topically Naphazoline can be absorbed into the systemic circulation and have systemic effects. The most likely development of systemic effects in children under 6 years old and the elderly. Diphenhydramine hydrochloride, systemic effects are unlikely.
The therapeutic effect develops within 5 min after instillation of the drug and lasts 8 hours.
Pharmacodynamics
Diphenhydramine blocks the H1 gistaminoretseptory. Reduces symptoms of allergies due to histamine release (including capillary permeability). Possesses antiallergic activity has mestnoanesteziruyuschee, antispasmodic and moderate ganglioblokiruyuschie action.Causes sedation and the hypnotic effect, has a moderate antiemetic effect, and also has a central holinoliticheskoy activity.
Naphazoline has α - adrenomimeticheskoe action. Causes prolonged peripheral vasoconstriction. Increases blood pressure, increases the pupil.
Indications for use
Acute rhinitis, inflammation of the maxillary cavities, nasal bleeding, allergic conjunctivitis and other allergic diseases, laryngitis, Eustace, swelling of the mucous after surgical benefits.